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Further studies are needed to assess the efficacy of anakinra in other selected groups of patients with more severe COVID-19 (The CORIMUNO-19 collaborative group, 22 January 2021). This is expected to reduce the need for hospitalisation in patients with mild to moderate COVID-19. Based on the passage, an excessive secretion of thyrotropes leads to an excess amount of TSH, or thyroid-stimulating hormone. TSH stimulates the thyroid to release T3 and T4, so unregulated high TSH levels leads to high T3 and T4. The high levels of T3 and T4 lead to a high basal metabolic rate, which leads to weight loss. Vasodilation of heart and lungs is a stress response mediated by cortisol and corticotropes . Somatotropes include human growth hormone and are unrelated to thyrotropes . Cortisol belongs to a subclass of steroid hormones known as glucocorticoids. 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